Tumor Anti-Angiogenesis Optimal Control Problem

The tumor anti-angiogenesis optimal control problem is stated as follows. Minimize the cost functional

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subject to the dynamic constraints

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the boundary conditions

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the integral constraint

eqn6113

and the control inequality path constraint

eqn6113

The solution to the tumor anti-angiogenesis optimal control problem with tf=10000 using GPOPS-II is shown in the figures below.

tumorAntiAngiogenesisStatetumorAntiAngiogenesisControl